How to Take CBD Oil – Sublingual Administration

CBD oil bottle and dropper

Understanding the way CBD oil affects the body is complex. Most people don’t have the time to navigate the research and technical terms that describe precisely how CBD works. Yet, as difficult as it is to grasp the chemical changes that take place after taking CBD, it is crucial to achieving results.

How Does CBD Work?

When we take CBD, there is a chemical response in our bodies. Scientists have proved this phenomenon in vitro (test tube) using cloned receptors. We’ve also seen the proof in human bodies, measuring changes in the activity of receptors that control the balance of cannabis-like compounds called endocannabinoids.


The chemical balance in our bodies and the reaction to external events are believed to be influenced by endocannabinoids. These neurotransmitters are regulated by enzymes such as fatty acid amide hydrolase (FAAH).

Anandamide, also known as the ‘bliss molecule,’ is one of the two main endocannabinoids we are currently aware of. If you’ve ever experienced a runner’s high, you have anandamide to thank. FAAH inhibits the production of anandamide, resulting in lower levels of a molecule that rewards our behavior. When we take CBD, levels of anandamide increase because FAAH is inhibited, creating a balanced chemical to exterior events.


The mechanism of creating balance in our bodies is done through endocannabinoid receptors. While CBD doesn’t have the affinity to bind with the two types of receptors we know of, CB1 and CB2, endocannabinoids do. The combination of endocannabinoids, CB receptors, and enzymes is known as the endocannabinoid system (ECS).

Most animals possess an ECS. Scientists believe the network of receptors, neurotransmitters, and enzymes is responsible for regulating many of our body’s responses, such as mood, memory, appetite, inflammation, anxiety, and the sleep-wake cycle.

How to Take CBD Oil

Many first-time CBD users are underwhelmed by the lack of life-changing effects they experience shortly after taking it. When taking CBD for the first time, you want to evaluate several factors before you begin:

  • Why are you taking CBD? Some people decide to use CBD to find relief from a condition, and others simply seek a daily balance. Depending on your reason for using CBD and the desired results, you may need to take a higher or lower dose.
  • Are you taking the correct dose? Being a natural product, and given all the variables that can influence the correct serving, it may be hard to calculate the “perfect” dosage.
  • Are you using a high-quality CBD product? Unfortunately, not everyone crafts their products the same way. Therefore, it is essential to be aware of ingredients you should avoid in your CBD and learn how to identify a High-Quality CBD product.

Once you have those points covered and begin establishing a CBD routine, you should consider the best absorption method and consistency to ensure CBD has built into your system before analyzing results.

Sublingual Administration

CBD oil is best absorbed when placed under the tongue for 60 to 90 seconds and then swallowed. This way, the effects are not decreased by digestion. The sublingual method allows it to enter the bloodstream faster and interact with the endocannabinoid system.

Once CBD is in our bloodstream, it can be delivered to the area where the enzymes exist. FAAH is primarily located in the brain. FAAH and anandamide are just one specific example of how CBD can alter our chemical composition. CBD can inhibit other enzymes and change the structure of CB receptors, creating a different effect when other cannabinoids (THC) interact with the brain.

Maximize Absorption

Another method that helps deliver as much CBD to the bloodstream as possible is to take CBD on a full stomach, preferably after a meal high in healthy fats. Researchers at the University of Minnesota conducted a study that found CBD levels are much higher after taking CBD on a full stomach.

Use Daily

A consistent dose is key to building up CBD and increasing the production of endocannabinoids.

Establish a Routine for Results

Taking CBD at least once per day is recommended when trying to achieve specific results. Putting yourself in the best possible position to feel the effects of CBD requires consistent use and maximizing absorption. After building up CBD in the body, you may experience the benefits that everyone can’t stop raving about. Establishing a regular CBD routine is a great way to make sure you get your dose and perform practices that lead to maximum absorption. 

Ready to start your CBD routine?

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